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Goal

Goals of this course

You should be able to recognize the correlation between different data and values from an  1H-NMR- spectrum and the proton arrangement in a chemical compound; and apply this knowledge:

Value in spectrum  Protons 
Number of resonance signals  Number of equivalent groups of protons 
Frequency of resonance signals  Type of protons 
Intensity of resonance signals  Number of protons contributing to the signal 
Line-splitting of resonance signals  Spatial conformation of the protons 

Therefore you should be able to
  1. decide which protons in a compound are chemically equivalent; 
  2. realize that methyl- and methylene protons in flexible systems only show one shared signal; 
  3. use tables with the expected values for proton chemical shifts; 
  4. Conversion of chemical shift data between  Dn, d or t;
  5. interprete the integrals of NMR spectra; 
  6. predict the relative intensities of proton signals; 
  7. explain the line-splitting of signals due to indirect spin-spin coupling in simple cases; 
  8. predict the multiplicity of the line splitting caused by non-equivalent neighboring protons; 
  9. predict the relative intensities of the lines in a multiplet caused by coupling to a neighboring proton; 
  10. decide whether coupling will occur between two protons; 
  11. determin the coupling constant based on a spectrum; 
  12. know that the coupling constant is independent from the frequency of the spectrometer; realize that "first-order"-spectra are only obtained under very specific conditions, and that most spectra are considerably more complicated. 
You should be able to predict the expected "first-order" spectrum based on the structure of a given compound, and vice versa select the correct stereo isomer based on a given first-order spectrum.